![]() Despite this long survival time, 50-75% of these patients die as a result of either tumor recurrence or malignant progression 6,11. The median survival of patients with LGG is between five and ten years 4-11. Peak incidence occurs in individuals between 35 and 44 years of age 3. These cases are predominantly astrocytomas. These tumors are classified according to cell origin and graded based on standard histopathological features defined by the World Health Organization (WHO) - Classification of Tumors of the Central Nervous System (latest 2007 edition) 1,2.ĭiffuse low-grade gliomas (LGGs), designated as WHO grade II classification, encompass glial tumors that are infiltrative in nature with low proliferative activity, including astrocytomas, oligodendrogliomas and mixed oligoastrocytomas.Īn estimated 2,000 to 3,000 LGGs are diagnosed in the United States every year, accounting for nearly 15% of all primary brain tumors. The most common tumors are collectively referred to as gliomas. Primary central nervous system (CNS) tumors comprise a heterogeneous group of benign and malignant neoplasms. Palavras-Chave: astrocitoma, análise de sobrevida, neurocirurgia. Key words: astrocytoma, survival analysis, neurosurgery. IIIDepartment of Neurology and Neurosurgery, Hospital de Câncer de Barretos, Barretos SP Brazil IIDepartment of Neurology, Hospital das Clínicas, USP Medical School, São Paulo SP, Brazil IPost-graduate student, Department of Neurology, Universidade de São Paulo (USP) Medical School, São Paulo SP, Brazil Almeida III Clemar Correa da Silva II Manoel Jacobsen Teixeira II Suely K. Low-grade astrocytoma : surgical outcomes in eloquent versus non-eloquent brain areasĪstrocitoma de baixo grau : resultado cirúrgico em área eloquente versus não eloquenteĪndré de Macedo Bianco I Flavio Key Miura II Carlos Clara III Jose Reynaldo W. ![]() A extensão da ressecção é fator preditivo de sobrevida tanto nas lesões em áreas eloquentes quanto nas não eloquentes.Īstrocitoma análise de sobrevida neurocirurgia Nos pacientes com lesão em áreas eloquentes, a sobrevida geral foi de 4,5 e 2,1 anos (p=0,33), respectivamente. A sobrevida geral foi de 4,7 e 1,9 anos em pacientes com lesões em área não eloquente submetidos à GTR/STR e biópsia (p=0,013). Nos pacientes com lesão em área não eloquente foram realizadas GTR, STR e biópsia em 31, 48 e 21% dos casos, enquanto, naqueles com lesão em área eloquente, em 22,5, 35 e 42,5%, respectivamente. O grau da ressecção cirúrgica foi classificado como ressecção total (GTR), subtotal (STR) e biópsia. A extensão da ressecção cirúrgica foi analisada para avaliar a sobrevida geral (OS) e o tempo livre de doença (PFS). ![]() Improved outcome for adult patients with LGA is predicted by more aggressive surgery in both eloquent and non-eloquent brain areas.Īstrocytoma survival analysis neurosurgeryįoi realizado estudo retrospectivo em 81 pacientes com astrocitoma de baixo grau (LGA) comparando a eficácia da ressecção cirúrgica com cirurgia menos agressiva em relação à área eloquente e não eloquente do cérebro. ![]() Overall survival was 4.7 and 1.9 years in patients with tumors in non-eloquent brain areas submitted to GTR/STR and biopsy (p=0.013), whereas overall survival among patients with tumors in eloquent area was 4.5 and 2.1 years (p=0.33). GTR, STR and biopsy in patients with tumors in non-eloquent areas were performed in 31, 48 and 21% subjects, whereas in patients with tumors in eloquent areas resections were 22.5, 35 and 42.5%. Degree of tumor resection was classified as gross total resection (GTR), subtotal resection (STR) or biopsy. Extent of surgical resection was analyzed to assess overall survival (OS) and progression- free survival (PFS). A retrospective study of 81 patients with low-grade astrocytoma (LGA) comparing the efficacy of aggressive versus less aggressive surgery in eloquent and non-eloquent brain areas was conducted.
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